College Saint Andre ni ikigo cy'amashuri yisumbuye cya Arkidiyosezi ya Kigali, cyatangiye mu mwaka 1957. College Saint Andre iherereye i Nyamirambo mu akarere ka Nyarugenge mu mujyi wa Kigali. Iri shuri ryatangiriye i Rwamagana ku gitekerezo cya Musenyeri A. Charrue na Chanoine Jacques
hamwe n'abapadiri b'abamisiyoneri Cuvelier, Reginald Griend na Jacque Noel Namur mu Bubiligi, ishingwa ry'iri shuri ryayobowe na Musenyeri Andrew Perraudin. College Saint Andre yatangiye yigisha ubuvanganzo harimo ikiratini n'ikigereki, nyuma ryaje kuba ishuri rya mbere ritangije kwigisha siyance mu Rwanda ryatangiye ryigisha ibinyabuzima n'ubutabire, imibare, ubugenge n'ubumenyi mbonezamubano. Mu 1958, College Saint Andre yaje kwimurirwa muri St Famille i Kigali. Mu 1962, ryimuriwe i Nyamirambo aho riri ubu, imirimo yo kuryubaka yasojwe mu 1964.
College Saint Andre ni ishuri ryigamo abahungu n'abakobwa bacumbikirwa